![]() Knot delineates class IV arbor morphology by simultaneously synergizing with Cut to promote complexity and repressing Cut-mediated promotion of dendritic filopodia/spikes. Knot and Cut control different aspects of the dendrite cytoskeleton, promoting microtubule- and actin-based dendritic arbors, respectively. ![]() We show that the combination of the transcription factors Knot and Cut is particular to Drosophila class IV dendritic arborization (da) neurons. ![]() Different neuronal classes are defined by class-specific transcription factor combinatorial codes. ![]() In a complex nervous system, neuronal functional diversity is reflected in the wide variety of dendritic arbor shapes.
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